Publications

Selected Publications

Full list of peer-reviewed papers

(P33) Zarei, S.; Motard, M.; Cecioni, S., Stable Amide Activation of N-Acetylated Glycosamines for the Synthesis of Fused Polycyclic Glycomimetics. Org. Lett., 2024, 26, 204-209.

 

(P32) Leclerc, C.; St-Gelais, J.; Cecioni, S.; Giguère, D. Synthesis and hydrolysis of aryl fluoroglycosides. J. Fluorine Chem., 2024, 273, 110232.

(P31) Bousch, C.; Vreulz, B.; Kansal, K.; El-Husseini, A.; Cecioni, S., Fluorogenic Photo-Crosslinking of Glycan-Binding Protein Recognition Using a Fluorinated Azido-Coumarin Fucoside. Angew. Chem. Int. Ed., 2023, e202314248.

(P30) Cecioni, S*; Ashmus, R. A. *; Gilormini, P.-A.; Zhu, S.; Chen, X.; Shan, X.; Gros, C.; Deen, M.; Wang, Y.; Britton, R.; Vocadlo, D. J., Quantifying lysosomal glycosidase activity within cells using bis-acetal substrates., Nature Chem. Biol.  2022, 18, 332-341.

(29) Zhu, Y.; Willems, L. I.; Salas, D.; Foster, L. J.; Cecioni, S.; Vocadlo, D. J., Tandem bioorthogonal labeling uncovers endogenous co-translationally O-GlcNAc modified nascent proteins., J. Am. Chem. Soc. 2020, 142, 15729-15739.

 

(28) Matthews, S. E.; Cecioni, S.; O’Brien, J. E.; MacDonald, C. J.; Hughes, D. L.; Jones, G. A.; Ashworth, S. H.; Vidal, S., Fixing the Conformation of Calix[4]arenes: When Are Three Carbons Not Enough? Chem. Eur. J., 2018, 24 (17), 4436-4444.

    

 

(27) Seo, I. K.; Woo, E. H.; Cecioni, S.; Vocadlo, D. J., A divergent synthesis to generate targeted libraries of inhibitors for endo-N-acetylglucosaminidases. Can. J. Chem., 2018, 96 (2), 248-254.

 

(26) Cecioni, S.; Vocadlo, D. J., Carbohydrate Bis-acetal-Based Substrates as Tunable Fluorescence-Quenched Probes for Monitoring exo-Glycosidase Activity. J. Am. Chem. Soc., 2017, 139 (25), 8392-8395.

 

(25) Shen, D. L.; Liu, T.-W.; Zandberg, W.; Clark, T.; Eskandari, R.; Alteen, M. G.; Tan, H. Y.; Zhu, Y.; Cecioni, S.; Vocadlo, D., Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose. ACS Chem. Biol.2017, 12 (1), 206-213.


(24) Liu, T.-W.; Myschyshyn, M.; Sinclair, D. A.; Cecioni, S.; Beja, K.; Honda, B. M.; Morin, R. D.; Vocadlo, D. J., Genome-wide chemical mapping of O-GlcNAcylated proteins in Drosophila melanogaster. Nature Chem. Biol., 2017,13 (2), 161-167.

 

(23) Zhu, Y.; Liu, T.-W.; Madden, Z.; Yuzwa, S. A.; Murray, K.; Cecioni, S.; Zachara, N.; Vocadlo, D. J., Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter. J. Mol. Cell Biol., 2016, 8 (1), 2-16.

 

(22) Cecioni, S.; Aouadi, K.; Guiard, J.; Parrot, S.; Strazielle, N.; Blondel, S.; Ghersi-Egea, J.-F.; Chapelle, C.; Denoroy, L.; Praly, J.-P., Novel routes to either racemic or enantiopure α-amino-(4-hydroxy-pyrrolidin-3-yl)acetic acid derivatives and biological evaluation of a new promising pharmacological scaffold. Eur. J. Med. Chem. 2015, 98, 237-249.

 

(21) Zhu, Y.; Liu, T.-W.; Cecioni, S.; Eskandari, R.; Zandberg, W. F.; Vocadlo, D. J., O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains. Nature Chem. Biol. 2015, 11 (5), 319-325.

 

(20) Cecioni, S.; Imberty, A.; Vidal, S., Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands. Chem. Rev. 2015, 115 (1), 525-561.

 

(19) Boukerb, A. M.; Rousset, A.; Galanos, N.; Méar, J.-B.; Thépaut, M.; Grandjean, T.; Gillon, E.; Cecioni, S.; Abderrahmen, C.; Faure, K.; Redelberger, D.; Kipnis, E.; Dessein, R.; Havet, S.; Darblade, B.; Matthews, S. E.; de Bentzmann, S.; Guéry, B.; Cournoyer, B.; Imberty, A.; Vidal, S., Antiadhesive Properties of Glycoclusters against Pseudomonas aeruginosa Lung Infection. J. Med. Chem., 2014, 57 (24), 10275-10289.

 

(18) Wang, S.; Galanos, N.; Rousset, A.; Buffet, K.; Cecioni, S.; Lafont, D.; Vincent, S. P.; Vidal, S., Fucosylation of triethyleneglycol-based acceptors into ‘clickable’ α-fucosides. Carbohydr. Res., 2014, 395, 15-18.

 

(17) Cecioni, S.; Vocadlo, D. J., Tools for probing and perturbing O-GlcNAc in cells and in vivo. Curr. Opin. Chem. Biol., 2013, 17 (5), 719-728.

 

(16) Gening, M. L.; Titov, D. V.; Cecioni, S.; Audfray, A.; Gerbst, A. G.; Tsvetkov, Y. E.; Krylov, V. B.; Imberty, A.; Nifantiev, N. E.; Vidal, S., Synthesis of Multivalent Carbohydrate-Centered Glycoclusters as Nanomolar Ligands of the Bacterial Lectin LecA from Pseudomonas aeruginosa. Chem. Eur. J., 2013, 19 (28), 9272-9285.

 

(15) Gerland, B.; Goudot, A.; Pourceau, G.; Meyer, A.; Dugas, V.; Cecioni, S.; Vidal, S.; Souteyrand, E.; Vasseur, J.-J.; Chevolot, Y.; Morvan, F., Synthesis of a Library of Fucosylated Glycoclusters and Determination of their Binding toward Pseudomonas aeruginosa Lectin B (PA-IIL) Using a DNA-Based Carbohydrate Microarray. Bioconjug. Chem., 2012, 23 (8), 1534-1547.

 

(14) Cecioni, S.; Praly, J.-P.; Matthews, S. E.; Wimmerová, M.; Imberty, A.; Vidal, S., Rational Design and Synthesis of Optimized Glycoclusters for Multivalent Lectin–Carbohydrate Interactions: Influence of the Linker Arm. Chem. Eur. J., 2012, 18 (20), 6250-6263.

 

(13) Cecioni, S.; Matthews, S. E.; Blanchard, H.; Praly, J.-P.; Imberty, A.; Vidal, S., Synthesis of lactosylated glycoclusters and inhibition studies with plant and human lectins. Carbohydr. Res., 2012, 356, 132-141.

 

(12) Chen, Y.; Vedala, H.; Kotchey, G. P.; Audfray, A.; Cecioni, S.; Imberty, A.; Vidal, S.; Star, A., Electronic Detection of Lectins Using Carbohydrate-Functionalized Nanostructures: Graphene versus Carbon Nanotubes. ACS Nano, 2012, 6 (1), 760-770.

 

(11) Soomro, Z. H.; Cecioni, S.; Blanchard, H.; Praly, J.-P.; Imberty, A.; Vidal, S.; Matthews, S. E., CuAAC synthesis of resorcin[4]arene-based glycoclusters as multivalent ligands of lectins. Org. Biomol. Chem., 2011, 9 (19), 6587-6597.

 

(10) Pourceau, G.; Chevolot, Y.; Goudot, A.; Giroux, F.; Meyer, A.; Moulés, V.; Lina, B.; Cecioni, S.; Vidal, S.; Yu, H.; Chen, X.; Ferraris, O.; Praly, J.-P.; Souteyrand, E.; Vasseur, J.-J.; Morvan, F., Measurement of Enzymatic Activity and Specificity of Human and Avian Influenza Neuraminidases from Whole Virus by Glycoarray and MALDI-TOF Mass Spectrometry. ChemBioChem, 2011, 12 (13), 2071-2080.

 

(9) Sicard, D.; Cecioni, S.; Iazykov, M.; Chevolot, Y.; Matthews, S. E.; Praly, J.-P.; Souteyrand, E.; Imberty, A.; Vidal, S.; Phaner-Goutorbe, M., AFM investigation of Pseudomonas aeruginosa lectin LecA (PA-IL) filaments induced by multivalent glycoclusters. Chem. Commun., 2011, 47 (33), 9483-9485.

 

(8) Vedala, H.; Chen, Y.; Cecioni, S.; Imberty, A.; Vidal, S.; Star, A., Nanoelectronic Detection of Lectin-Carbohydrate Interactions Using Carbon Nanotubes. Nano Lett., 2011, 11 (1), 170-175.

 

(7) Cecioni, S.; Faure, S.; Darbost, U.; Bonnamour, I.; Parrot-Lopez, H.; Roy, O.; Taillefumier, C.; Wimmerová, M.; Praly, J.-P.; Imberty, A.; Vidal, S., Selectivity among Two Lectins: Probing the Effect of Topology, Multivalency and Flexibility of “Clicked” Multivalent Glycoclusters. Chem. Eur. J., 2011, 17 (7), 2146-2159.

 

(6) Cecioni, S.; Oerthel, V.; Iehl, J.; Holler, M.; Goyard, D.; Praly, J.-P.; Imberty, A.; Nierengarten, J.-F.; Vidal, S., Synthesis of Dodecavalent Fullerene-Based Glycoclusters and Evaluation of Their Binding Properties towards a Bacterial Lectin. Chem. Eur. J., 2011, 17 (11), 3252-3261.

 

(5) Nierengarten, J.-F.; Iehl, J.; Oerthel, V.; Holler, M.; Illescas, B. M.; Munoz, A.; Martin, N.; Rojo, J.; Sanchez-Navarro, M.; Cecioni, S.; Vidal, S.; Buffet, K.; Durka, M.; Vincent, S. P., Fullerene sugar balls. Chem. Commun., 2010, 46 (22), 3860-3862.

 

(4) Berson, S.; Cecioni, S.; Billon, M.; Kervella, Y.; de Bettignies, R.; Bailly, S.; Guillerez, S., Effect of carbonitrile and hexyloxy substituents on alternated copolymer of polythiophene–Performances in photovoltaic cells. Sol. Energy Mater. Sol. Cells, 2010, 94 (5), 699-708.

 

(3) Cecioni, S.; Lalor, R.; Blanchard, B.; Praly, J.-P.; Imberty, A.; Matthews, S. E.; Vidal, S., Achieving High Affinity towards a Bacterial Lectin through Multivalent Topological Isomers of Calix[4]arene Glycoconjugates. Chem. Eur. J., 2009, 15 (47), 13232-13240.

 

(2) Xue, J. L.; Cecioni, S.; He, L.; Vidal, S.; Praly, J.-P., Variations on the SnCl4 and CF3CO2Ag-promoted glycosidation of sugar acetates: a direct, versatile and apparently simple method with either α or β stereocontrol. Carbohydr. Res., 2009, 344 (13), 1646-1653.

 

(1) Cecioni, S.; Argintaru, O.-A.; Docsa, T.; Gergely, P.; Praly, J.-P.; Vidal, S., Probing multivalency for the inhibition of an enzyme: glycogen phosphorylase as a case study. New J. Chem., 2009, 33 (1), 148-156.